What are the applications of bio 3D printing artificial skin?

The combination of 3D printing technology and life science opens a door for the creation of artificial organs and tissues, and the creation of artificial skin is one of the applications that these disciplines explore. 3D printed artificial skin may change the skin repair treatment of burn patients and the test methods required during cosmetic development.

At present, in order to treat burn patients, it is necessary to transplant some healthy skin from the patient's body, but this will lead to more wounds in the patient, especially in the treatment of patients with extensive burns, this method has certain drawbacks. Artificial skin manufactured by biological 3D printing is expected to replace human skin transplantation, and artificial skin to repair burned skin.

The Graduate School of Biomedical and Mechanical Engineering at the University of Toronto has conducted research on bio-3D printed artificial skin. Through their research, we can get a general understanding of the manufacturing process and principles of 3D printed artificial skin.

The University of Toronto team developed a bio-based 3D printer that can generate large quantities of portable artificial skin in a relatively short period of time. Through this 3D printer, a hydrogel material called a "live bandage" can be extruded, which is made up of biopolymers, human keratinocytes (a kind of skin cells) and fibroblasts (ie in wounds). a honeycomb structure that plays a key role in healing.

During the extrusion process, the hydrogel material is printed as a discrete and clear honeycomb structure to mimic human skin. The application of this artificial skin tissue is to cover the skin wounds of human burns and promote the repair of burned skin.

Bio-3D printing technology mimics the structure of human skin tissue, creating artificial skin structures with different layers, namely the epidermal structure for protecting internal tissues, the thicker and deeper dermis, and the collagen produced by fibroblasts. Structure of elasticity and mechanical strength.

However, artificial skin made by biological 3D printing technology and active materials with human cells does not look like real skin. These skin tissues do not have hair follicles or pigmentation compared with real skin.

To solve these problems, researchers and scientists at the Singapore Institute of Manufacturing Technology (SIMTech) and the Nanyang Technological University 3D Printing Center (SC3DP) have developed a 3D printed coloring skin.

They use bio 3D printing to achieve even skin pigmentation. For artificial skin manufacturing technology, this research may be a big step forward because it can produce artificial skin that matches the skin color of the human body, which will promote the application of artificial skin technology in medical treatment. .

Bio-3D printed artificial skin tissue can be used as an alternative to animals for cosmetic testing. This technology has now entered the commercialization stage.

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